Cavaliers vs Spurs Picks and Prediction – 4/5/2025

By: David Anicetti |

Last Updated: 04/03/2025 at 8:43 PM ET

Cleveland Cavaliers at San Antonio Spurs 04/04/25 - NBA Picks & Predictions
Game Start: 4/5/2025, 12:00 AM UTC
Latest Odds: CLE -14 ; O/U 239.5

Cavaliers vs Spurs Prediction

The Cleveland Cavaliers look for a third straight win on Friday when visiting the San Antonio Spurs. Cleveland is 61-15 and first in the Eastern Conference, five games ahead of second-place Boston. The Cavaliers can clinch the regular season title with a victory on Friday. Cleveland defeated the New York Knicks 124-105 on Wednesday. The Cavaliers have won five of the last six. Keep up to date with all the NBA action with our NBA predictions.

Donovan Mitchell leads Cleveland in the scoring, averaging 24.0 points per game. Darius Garland is second in scoring and the leader in assists, averaging 20.6 points and 6.7 assists per game. Jarrett Allen is the leading rebounder, averaging 10.0 rebounds per game. Cleveland scores an average of 122.3 points per game, shooting 49.2% overall and 38.4% from 3-point territory.

The San Antonio Spurs look for a second consecutive win on Friday when hosting the Cleveland Cavaliers. San Antonio is 32-44 and 13th in the Western Conference. San Antonio trails the 10th and final qualifying spot for the postseason by three games with six games remaining on the regular season schedule. San Antonio defeated the Denver Nuggets 113-106 on Wednesday night, snapping a five-game losing streak.

Devin Vassell is leading San Antonio in scoring, averaging 16.3 points per game, and Stephon Castle is second, averaging 16.3 points per game. Chris Paul is the leader in assists at 7.5 per game, and Jeremy Sochan is the leading rebounder, averaging 6.5 rebounds per game. San Antonio scores an average of 114.0 points per game, shooting 46.5% overall and 35.6% from 3-point territory.

Cavaliers vs Spurs Pick Analysis

The Cleveland Cavaliers will win and clinch the Eastern Conference regular season title on Friday when visiting the San Antonio Spurs, but the play here is OVER. The OVER has cashed in four of Cleveland's last five, four of San Antonio's last five, nine of San Antonio's last 11 played at home, and eight of San Antonio's last 11 head-to-head versus Cleveland. Final Score Prediction, Cleveland Cavaliers win but our best play is OVER 129-124.

Our Free NBA Pick for San Antonio Spurs vs Cleveland Cavaliers

Over 239.5