Nationals vs Pirates Picks and Prediction – 4/16/2025

The Washington Nationals play the third game of a four-game series on the road Wednesday versus the Pittsburgh Pirates. Washington dropped to 6-10 following its 10-3 loss to Pittsburgh on Monday in the opening game of the series. Washington has lost three straight and four of the last five. The Nationals are 4th in the National League East, five games behind the first-place New York Mets. Keep up to date with all the MLB action with our MLB predictions.

Keibert Ruiz is batting .364 with 20 hits and an on-base percentage of .426 to lead Washington in the three statistics. James Wood is the leader in home runs with five, and Nathaniel Lowe is the leader in RBI with 16. Washington is batting .235 with a .391 slugging percentage. On Wednesday, Washington will send Mitchell Parker to the mound. The left-hander is 2-0 with a 1.99 ERA, 10 Ks, and 8 BBs.

The Pittsburgh Pirates improved to 6-11 following Monday’s seven-run victory over the Washington Nationals. Pittsburgh star Paul Skenes gave up one run on three hits across six Innings with six strikeouts to earn the victory. The Pirates snapped a three-game winning streak with the win. Pittsburgh is last in the National League Central, four games behind the first-place Chicago Cubs.

Isiah Kiner-Falefa is batting .264 to lead Pittsburgh. Bryan Reynolds is the leader in home runs with two and hits with 15. Ke’Bryan Hayes is the leader in RBI with eight, and Oneil Cruz is the leader in on-base percentage at .356. On Wednesday, the Pittsburgh Pirates will send Bailey Falter to the mound. The left-hander is 0-2 with a 7.20 ERA, 13 Ks, and 6 BBs. 

Washington will win on the road Wednesday versus Pittsburgh, but the play here is OVER. The OVER has cashed in each of Washington's last eight and five of Washington's last six versus Pittsburgh. Washington starter Mitchell Parker was hit hard last time out, allowing three runs on five hits across six innings. Pittsburgh starter Bailey Falter has been hit hard in two straight, all around 10 runs across 9 Innings. Final Score Prediction: Washington Nationals win but our best play is OVER 6-5.