Nationals vs Orioles Picks and Prediction – 5/17/2025

Beautiful Camden Yards will play host to a Saturday afternoon MLB interleague clash between the Washington Nationals and the Baltimore Orioles. Be ready for the baseball season with all of our MLB predictions. The Nationals (19-27) have dropped eight of their last ten games and are 9.5 games out of first place in the NL East Division. Last night, James Wood hit a game-tying solo shot in the eighth inning and Washington scratched a run in the next frame to earn a 4-3 road victory against Baltimore. 

Twenty-eight year old righty Jake Irvin (2-1 4.00 ERA) will make his tenth start of the year for the Nationals. Last time out, Irvin (6 IP) gave up seven hits and three runs during a 4-3 road loss against Atlanta. 

The Baltimore Orioles rank near the bottom of the majors with a 5,34 ERA and are trapped in the AL East Division basement. During Friday’s home loss, Washington batters struck out 15 times and left 15 men on base. OF Ramon Laureano went 4-for-4 with a run scored in a losing effort for the Nationals (15-28), who fell to 8-13 at home. 

Thirty-seven year old righty Kyle Gibson (0-2 13.11 ERA) is off to a disastrous start for the Orioles. Through 11 plus innings, Gibson has surrendered seven long balls and owns an alarming 2.49 WHIP.

Baltimore 2B Jordan Westburg (hamstring) suffered a setback in his recovery and is without a timetable to return. Through 46 games, Washington ranks 21st in OPS and 16th in runs scored. For the season, Baltimore ranks 23rd in OPS and 25th in runs scored. Take the over. Final Score Prediction, Baltimore Orioles win 6-4.