Nationals vs Orioles Picks and Prediction – 5/16/2025

The Washington Nationals open a three-game series on the road Friday versus the Baltimore Orioles. Washington is 18-26 following its 5-4 victory over the Atlanta Braves on Wednesday. The win snapped a seven-game losing streak by the Nationals. Washington is fourth in the National League East, 10 games behind the first-place New York Mets. Keep up to date with all the MLB action with our expert MLB picks.

CJ Abrams is batting .311 to lead Washington and has a team-high .375 on-base percentage. James Wood is the leader in home runs with 11 and hits with 46. Nathaniel Lowe is the leader in RBI with 30. Washington is batting .239 with a .378 slugging percentage. On Friday, Washington will send MacKenzie Gore to the mound. The left-hander is 2-4 with a 3.59 ERA, 75 Ks, and 16 BBs.

The Baltimore Orioles dropped to 15-26 following Wednesday’s 8-6 loss to the Minnesota Twins in the second game of a doubleheader. The Orioles were swept in the doubleheader after losing game one 6-3. Baltimore has lost two straight and eight of the last 10. The Orioles are last in the American League East, nine games behind the first-place New York Yankees.

Gunnar Henderson is batting .275 with 38 hits to lead Baltimore in both categories. Cedric Mullins is the leader in home runs with eight, RBI with 25, and on-base percentage at .335. Baltimore is batting .227 with a .384 slugging percentage. On Friday, the Baltimore Orioles will send Kyle Gibson to the mound. The right-hander is 0-2 with a 13.11 ERA, 9 Ks, and 6 BBs. 

Baltimore will win at home on Friday when hosting Washington, but the play here is OVER. The OVER has cashed in three of the Orioles' last four. Both teams have starting pitchers who have struggled this season. Washington starter Mackenzie Gore was roughed up last time out, allowing four runs on five hits across 6.2 innings. Baltimore starter Kyle Gibson has been hit hard in three consecutive outings, allowing 17 runs on 23 hits across 9.2 innings. Final Score Prediction: Baltimore Orioles win but our best play is OVER 7-5.