Blue Jays vs Cardinals Picks and Prediction – 6/10/2025

The Blue Jays (35-30) travel to St. Louis to take on the Cardinals (36-29) at Busch Stadium on June 10 at 5:45 PM EST. Toronto is coming off a 6-3 loss to the Twins, while the Cardinals just dropped one to the Dodgers, 7-3. The pitching matchup features Chris Bassitt (6-3, 3.56 ERA) for Toronto against Miles Mikolas (4-2, 3.96 ERA) for St. Louis. Elevate your MLB game with our top-notch MLB picks.

Toronto is 4-1 in its last five games, including a strong showing in Minneapolis with two wins before dropping the series finale. Bassitt has quietly been dependable, racking up 75 strikeouts over 73.1 innings and keeping the ball in the park decently with just 9 home runs allowed. The lineup has been steady, with George Springer supplying 10 homers and Bo Bichette leading with 37 RBIs. The team has managed a .252 batting average and .324 OBP while slugging at .395.

On the hill, the Blue Jays hold a 4.02 ERA and 1.22 WHIP. The bullpen is hurting, with multiple arms like Yimi Garcia and Ryan Burr on the IL. Still, opponents are hitting just .236 off Toronto pitching, which is solid. Despite a 13-17 road record, the numbers show a capable squad that’s just short on depth. Bassitt’s command will be key in this one, especially with the bullpen not fully healthy.

St. Louis enters this one after winning two of three against the Dodgers and five of the last seven overall. Mikolas takes the ball, looking to build off recent consistency, sitting at a 1.27 WHIP with just 4 long balls surrendered. The offense is led by Brendan Donovan batting .317, and Willson Contreras with 38 RBIs. The Cardinals are hitting .258 with a .329 OBP, and 301 total runs — more efficient than Toronto.

On the mound, St. Louis has been slightly better with a 3.87 ERA and a .249 OBA. Injuries to Jordan Walker and Zack Thompson sting, but the staff has held strong, walking just 180 over 61 games. The Cardinals’ 22-11 home record and solid run prevention at Busch give them a big edge. Mikolas doesn’t strike many out, but he keeps the ball down, and that's worked at home all year.

Toronto has been competitive lately, but the Cardinals' better home record, sharper ERA, and more consistent offense make the difference. Bassitt’s solid, but the depleted bullpen looms large, especially if Mikolas keeps pounding the zone and letting his defense work behind him. Final Score Prediction: St. Louis Cardinals win 5-4.