Blue Jays vs Mariners Picks and Prediction – 5/10/2025

Toronto (16-20) heads into T-Mobile Park to face Seattle (22-14) in a battle of right-handers, Kevin Gausman vs Luis Castillo. The Blue Jays dropped a close 5-4 game to the Angels, while the Mariners held off the Athletics 6-5. Gausman has posted a 3.83 ERA with a sharp 0.93 WHIP, while Castillo enters with a 3.29 ERA but a slightly elevated 1.33 WHIP. Elevate your MLB game with our top-notch MLB picks.

Toronto’s slide continues with four losses in the last five, including back-to-back series defeats to Cleveland and the Angels. Run production has been a serious issue—just 19 runs scored across that five-game stretch. Even with George Springer batting .304 and Vladimir Guerrero Jr. driving in 18 runs, the Blue Jays haven't been able to capitalize when it matters. Gausman has been solid, but the bullpen and lack of clutch hitting continue to hurt chances late in games.

The Blue Jays carry a 4.39 team ERA and have allowed 127 runs. The team’s 1.27 WHIP is respectable, but they’ve struggled to keep the ball in the yard with 25 homers allowed. They rank middle-of-the-pack in strikeouts with 333 and own a .240 opponent batting average. The bullpen has been hit with injuries—Nick Sandlin and Erik Swanson remain sidelined. Toronto has a 5-12 road record, and it’s clear the struggles extend beyond offense.

Seattle is heating up with wins in three of the last four and sits strong at 12-6 at home. Jorge Polanco is scorching at the plate, hitting .348 with 27 RBI, while Cal Raleigh leads the club with 12 homers. Castillo’s 3.29 ERA has been steady, and the Mariners’ lineup has outscored opponents by 58 runs so far this season. They’re finding different ways to win, including tight one-run battles like the latest against Oakland.

On the mound, Seattle owns a 3.75 team ERA and has only given up 122 walks across 36 games. The Mariners have limited long balls and lead the AL in homers with 51. Even without Logan Gilbert and George Kirby, the pitching depth is holding. Seattle's .247 average against isn't perfect, but the staff is getting it done when it counts, especially at home.

The Mariners are playing cleaner, more complete baseball with better power and more reliable arms. While Gausman might keep this close, Toronto’s offensive struggles and bullpen injuries make it tough to trust them in a hostile environment. Seattle’s stronger home record and better run differential tip this one to the Mariners. Final Score Prediction: Seattle Mariners win 5-3.