Blue Jays vs Yankees Picks and Prediction – 4/25/2025

By: Eddie Kline |

Last Updated: 04/24/2025 at 8:26 PM ET

Toronto Blue Jays at New York Yankees 04/25/25 - MLB Picks & Predictions
Game Start: 4/25/2025, 11:05 PM UTC
Latest Odds: NYY -142 ; O/U 10

Blue Jays vs Yankees Prediction

AL East Division rivals will square off on Friday night, when the Toronto Blue Jays invade the Bronx to take on the New York Yankees. Be ready for the baseball season with all of our MLB predictions. The Blue Jays (12-13) are looking to snap a five-game losing streak and have scored just two runs over their last 27 innings. On Wednesday, Toronto SP Bowden Francis (2-3) gave up three runs in four plus innings during a 3-1 road loss against Houston. 

Thirty year old right-hander Jose Berrios (1-1 5.02 ERA) will take the ball for the Blue Jays in the series opener. Control has been an issue for Berrios, who has walked 13 batters and surrendered six long balls across 28 plus frames. 

The New York Yankees have won eight of their first 12 home games and hold a 1.5 game lead over Boston for first place. On Wednesday, veteran DH Paul Goldschmidt went 3-for-5 and drove in a pair of runs to lead New York to a 5-1 road victory against Cleveland. SP Carlos Rodon (3-3) struck out eight batters in seven innings to earn the win for the Yankees, who improved to 15-10 overall.

New York manager Aaron Boone will counter with veteran right-hander Carlos Carrasco (2-1 6.53 ERA) on Friday. Last time out, Carrasco (4 IP) gave up six hits and four runs during a 10-8 road loss against Tampa Bay. 

Blue Jays vs Yankees Pick Analysis

New York DH Giancarlo Stanton (elbow) took batting practice on the field on Tuesday and hopes to make his season debut later next month. Through 25 games, Toronto ranks 24th in OPS and 25th in runs scored. For the regular season, New York ranks 2nd in OPS and 2nd in runs scored. Take the Blue Jays to win on the road. Final Score Prediction, Toronto Blue Jays win 6-4.

Our Free MLB Pick for New York Yankees vs Toronto Blue Jays

Toronto Blue Jays +120