Blue Jays vs Astros Picks and Prediction – 4/23/2025

This Tuesday, Chris Bassitt and the Toronto Blue Jays head to Minute Maid Park to take on Ronel Blanco and the Houston Astros in a battle between both sides looking to find early-season consistency. Get our free MLB Picks all season long! The Blue Jays, now 12-10, are coming off an 8-3 loss to the Mariners on Sunday and aim to bounce back behind one of their most reliable arms.

Bassitt has had a steady start to the year, using his diverse pitch mix to keep hitters off balance. Toronto’s offense has been streaky, and they’ll need better production with runners in scoring position to back Bassitt against a capable Astros lineup.

Houston enters the series at 10-11 following a narrow 3-2 loss to the Padres. Blanco takes the mound after throwing a no-hitter earlier this month and has emerged as one of the Astros’ biggest surprises. His fastball-changeup combo has been particularly effective, and he’ll look to shut down Toronto’s top bats early.

The key for Toronto will be making Blanco work deep into counts and avoiding early outs, while Houston needs to give their starter some early run support after multiple close games. Both sides are built for postseason contention and will treat this series as a tone-setter.

With Blanco dealing and the Astros returning home, Houston may have the edge in a tight, well-pitched game. If Bassitt keeps things close, this could go down to the late innings. Expect this one to be close, but for the Astros to leave with the win. Final Score Prediction, Houston Astros win 4-3.