Blue Jays vs Astros Picks and Prediction – 4/22/2025

The Toronto Blue Jays open a three-game series on the road Monday versus the Houston Astros. Toronto is 12-9 following its 8-4 loss to the Seattle Mariners on Saturday. The loss snapped a three-game winning streak by the Blue Jays. Toronto is second in the American League East, just one game behind the first-place New York Yankees. Keep up to date with all the MLB action with our MLB predictions.

George Springer is batting .351 with an on-base percentage of .415 to lead Toronto in both categories. Andres Gimenez is the leader in home runs with three. Bo Bichette is the leader in RBI with 12 and hits with 28. Toronto is batting .256 with a .365 slugging percentage. On Monday, Toronto will send Kevin Gausman to the mound. The right-hander is 2-1 with a 2.49 ERA, 20 Ks, and 3 BBs.

The Houston Astros improved to 10-10 following Saturday’s 3-2 win over the San Diego Padres. Isaac Paredes hit a tie-breaking RBI single during the 7th inning. Christian Walker hit a two-run home run for the Astros. Houston has won three of the last four, but the Astros trail the first-place Texas Rangers in the American League West by 2 ½ games.

Jose Altuve is batting .305 with three home runs and 25 hits to lead Houston in each of the three categories. Isaac Paredes is the leader in RBI with 11 and on-base percentage with .352. Houston is batting .223 with a .334 slugging percentage. On Monday, Houston will send Hunter Brown to the mound. The right-hander is 2-1 with a 1.50 ERA, 22 Ks, and 5 BBs.

Houston will win at home on Monday when hosting Toronto, but the play here is UNDER. The UNDER has cashed in 13 of Toronto's last 20 during April. Toronto starter Kevin Gausman has had four consecutive strong outings, allowing four runs across 25.1 innings, with Toronto winning three of the four. Houston starter Hunter Brown has had two consecutive shutout outings, allowing no runs on six hits across 12 innings. Final Score Prediction: Houston Astros win, but our best play is UNDER 4-2.