Blue Jays vs Guardians Picks and Prediction – 6/25/2025

The Toronto Blue Jays play the second game of a three-game series on the road Wednesday versus the Cleveland Guardians. Toronto is 41-36 and lost to the Chicago White Sox 4-2 on Sunday. Toronto has lost three of the last four. The Blue Jays were off on Monday. Toronto is third in the American League East, 3 ½ games behind the first-place New York Yankees. Keep up to date with all the MLB action with our MLB predictions.

Ernie Clement is batting .307 to lead Toronto. Bo Bichette leads Toronto in home runs with 11, RBI with 48, and hits with 91, while Vladimir Guerrero Jr leads in on-base percentage at .383. Toronto is batting .256 with a .401 slugging percentage. On Wednesday, Toronto will send Max Scherzer to the mound. The right-hander is 0-0 with a 6.00 ERA, 1 K, and 0 BBs.

The Cleveland Guardians improved to 39-37 following Sunday’s 3-0 victory over the Athletics. Slade Cecconi pitched seven strong innings for Cleveland, and closer Emmanuel Clase escaped a jam with the bases loaded in the 9th inning. Cleveland has won two straight and four of the last six, but the Guardians trail first-place Detroit by 8 ½ games in the American League Central.

Jose Ramirez is batting .323 with 13 home runs, 90 hits, and an on-base percentage of .383 to lead Cleveland in the four categories. Carlos Santana is the leader in RBI with 36. Cleveland is batting .230 with a .370 slugging percentage. On Wednesday, the Cleveland Guardians will send Gavin Williams to the mound. The right-hander is 5-3 with a 3.58 ERA, 78 Ks, and 42 BBs.

Cleveland has won four of its last six, and the Guardians have won five of the last six played at home versus the Blue Jays. Toronto starter Max Scherzer will be making his first appearance since March 29, when the veteran right-hander threw just three innings, allowing two runs before leaving with an injury. Cleveland starter Gavin Williams has had two consecutive strong outings, allowing two runs on eight hits across 10 innings. Final Score Prediction: Cleveland Guardians win 6-3.