Rays vs Padres Picks and Prediction – 4/27/2025

This Sunday, Zack Littell and the Tampa Bay Rays continue their series against Randy Vasquez and the San Diego Padres at Petco Park. Get our free MLB Picks all season long! The Rays, now 12-14, are coming off a tight 1-0 win over the Padres on Friday, riding strong pitching and timely defense to snap a short losing skid.

Littell has been a reliable arm for Tampa Bay, showing excellent control and keeping hitters off balance. In a pitcher’s park like Petco, his style could be even more effective if he works ahead in counts. The Rays’ offense still needs to find more consistency, but their pitching keeps them competitive.

The Padres enter at 17-9 despite Friday’s tough loss. Vasquez gets the start and will try to bounce back after some recent control struggles. San Diego’s lineup, loaded with power hitters like Fernando Tatis Jr. and Manny Machado, will look to be more opportunistic after being shut out.

This game could again be a low-scoring battle, putting pressure on both starting pitchers to execute and avoid mistakes. Tampa Bay’s ability to manufacture runs and play solid defense could be critical, while San Diego will look for a big inning to swing the momentum.

Tampa Bay’s pitching depth and Littell’s recent form give the Rays a slight edge in another close contest. San Diego will threaten, but if Tampa executes their small-ball approach, they can grind out another road win. Take the Rays to steal this one from the Padres. Final Score Prediction, Tampa Bay Rays win 3-2.