Rays vs Padres Picks and Prediction – 4/27/2025

The San Diego Padres remain at home on Saturday with the Tampa Bay Rays in town. The Padres lead the NL West with a 17-8 record. San Diego is playing .500 baseball over their last ten games. The Padres are averaging 4.1 runs scored per game with 8.6 hits. Stay up to date with our expert's MLB Picks. 

Dylan Cease will make his 6th start on the mound for the San Diego Padres. Cease is 1-1 on the season with 25.1 innings pitched. Cease has 30 strikeouts and carries a 6.04 ERA. Cease pitched at least 5 innings in each of his last two starts. 

The Tampa Bay Rays entered this series with a 11-4 record. The Rays are 4-6 over their last ten games. Tampa Bay carried a two game win streak into this series with a 2-4 road record. The Rays are averaging 4.4 runs scored per game with 8.5 hits. 

Ryan Pepiot will make his 6th start on the mound for the Tampa Bay Rays. Pepiot is 1-3 on the season with 28 innings pitched. Pepiot has 31 strikeouts and carries a 4.82 ERA. Pepiot pitched at least 6 innings in each of his last two starts. The Tampa Rays carry a 3.75 team ERA. 

The Tampa Bay Rays show value as an underdog. The Rays entered this series riding a two game win streak. San Diego has been one of the best teams on their home field. Watch for the Rays to grind out a road win. Final Score Prediction, Tampa Bay Rays win 4-2.