Cardinals vs Nationals Picks and Prediction – 5/10/2025

In Saturday afternoon MLB action, the St. Louis Cardinals and the Washington Nationals will continue their weekend series from Nationals Park. Be ready for the baseball season with all of our MLB predictions. The Cardinals (20-19) are riding a six-game winning streak and trail NL Central Division leading Chicago by 2.5 games. Last night, 1B Willson Contreras went 2-for-4 with three RBIs to spark St. Louis to a 10-0 road triumph.

Twenty-six year old righty Andre Pallante (2-2 4.75 ERA) will take the mound for the Cardinals in this matchup. In his last start, Pallante (3.1 IP) gave up nine hits and four runs during a 5-4 home victory versus New York. 

The Washington Nationals have split their first 20 road games and are sitting in fourth place in the NL East Division standings. During Friday’s home loss, leadoff hitter C.J. collected three of Washington’s five hits to raise his average to .304. SP Mitchell Parker (3-3) gave up four runs in four innings and took the loss for the Nationals, who fell to 17-22 overall.

Washington manager Dave Martinez will give the nod to veteran right-hander Trevor Williams (2-3 5.86 ERA) on Saturday. Last time out, Williams (5.1 IP) allowed nine hits and four runs during an 11-6 road victory against Cincinnati.

Washington 3B Paul DeJong is expected to be sidelined until July while recovering from surgery to repair his nose and sinuses. Through 39 games, St. Louis ranks 11th in OPS and 13th in runs scored. For the season, Washington ranks 15th in OPS and 14th in runs scored. Take the over. Final Score Prediction, St. Louis Cardinals win 6-5.