Cardinals vs Phillies Picks and Prediction – 5/14/2025

In the first game of a Wednesday day-night doubleheader, the St. Louis Cardinals will square off against the Philadelphia Phillies from Citizens Bank Park. Be ready for the baseball season with all of our MLB predictions. The Cardinals (23-19) are riding a nine-game winning streak and trail NL Central Division leading Chicago by one game. On Monday, SS Masyn Winn delivered a go-ahead solo shot in the seventh inning to lift St. Louis to a 3-2 road victory against Philadelphia. 

Thirty-two year old righty Erick Fedde (3-3 3.86 ERA) will make his ninth start of the year for the Cardinals. Last time out, Fedde went the distance and fanned eight batters during a 10-0 road triumph against Washington. 

The Philadelphia Phillies have won seven of their last ten games and are 2.5 games behind New York for first place in the NL East Division. During Monday’s home loss, Philadelphia batters went 1-for-7 with runners in scoring position and left eight men on base. C J.T. Realmuto went 2-for-4 with an RBI and a run scored for the Phillies (24-17), who fell to 13-7 at home. 

Philadelphia manager Rob Thomson will give the nod to flame-throwing lefty Jesus Luzardo (3-0 2.11 ERA) on Wednesday. Through 47 innings, Luzardo has struck out 51 batters and owns a solid 1.21 WHIP.

Philadelphia RP Jose Ruiz has been placed on the 15-day injured list with neck spasms. Through 42 games, St. Louis ranks 10th in OPS and 9th in runs scored. For the season, Philadelphia ranks 11th in OPS and 11th in runs scored. Take the under. Final Score Prediction, Philadelphia Phlllies win 5-2.