Cardinals vs Guardians Picks and Prediction – 6/27/2025

The St Louis Cardinals open a three-game series on the road Friday versus the Cleveland Guardians. St Louis is 44-37 following its 8-0 loss to the Chicago Cubs on Wednesday, snapping a two-game winning streak. St Louis has won seven of the last nine. The Cardinals are third in the National League Central, 3 ½ games behind the first-place Cubs. Keep up to date with all the MLB action with our MLB picks.

Brendan Donovan bats .305 with 87 hits and an on-base percentage of .372 to lead St Louis in each of the three categories. Lars Nootbaar leads in home runs with 11, and Willson Contreras leads in RBI with 50. St. Louis is batting .255 with a .396 slugging percentage. On Friday, St Louis will send Sonny Gray to the mound. The right-hander is 7-2 with a 3.72 ERA, 90 Ks, and 17 BBs.

The Cleveland Guardians improved to 40-38 following Wednesday’s 5-4 victory over the Toronto Blue Jays. Jose Ramirez hit a walk-off single in the bottom of the 10th inning to give Cleveland the victory. Cleveland has won three of the last four. The Guardians are second in the American League Central, 8 ½ games behind the first-place Detroit Tigers.

Jose Ramirez is batting .318 with 13 home runs, 38 RBI, 92 hits, and an on-base percentage of .378 to lead Cleveland in the five categories. Kyle Manzardo is second in home runs with 12. Cleveland is batting .231 with a .373 slugging percentage. On Friday, Cleveland will send Luis Ortiz to the mound. The right-hander is 4-8 with a 4.30 ERA, 91 Ks, and 41 BBs.

Cleveland will win at home on Friday when hosting St Louis, but the play here is UNDER. The UNDER has cashed in seven of Cleveland's last nine, and both starting pitchers are coming off solid outings. St Louis starter Sonny Gray is coming off a strong outing in which the right-hander allowed one run on five hits across five innings. Cleveland starter Luis Ortiz is coming off a strong outing in which the right-hander allowed no runs on two hits across six innings. Final Score Prediction, Cleveland Guardians win but our best play is UNDER 4-1.