Cardinals vs Reds Picks and Prediction – 5/1/2025

The Great American Ball Park will play host to a Thursday afternoon MLB clash between the St. Louis Cardinals and the Cincinnati Reds. Be ready for the baseball season with all of our MLB predictions. The Cardinals (14-17) have dropped 12 of their first 16 road games and are four games off the pace in the NL Central Division race. In the first game of yesterday’s doubleheader, SS Masyn Winn homered twice and SP Miles Mikolas fired five plus shutout innings to lead St. Louis to a 6-0 road victory against Cincinnati. 

Twenty-five year old lefty Matthew Liberatore (2-2 3.19 ERA) will take the mound for the Cardinals in this matchup. Through 31 innings of work, Liberatore has allowed just one long ball and fanned 28 batters white posting an impressive 0.97 WHIP.

The Cincinnati Reds rank seventh in the majors with a 3.37 ERA and trail NL Central Division leading Chicago by two games. In the second game of Wednesday’s doubleheader, Cincinnati batters went 1-for-8 with runners in scoring position and left six men on base during a 9-1 home loss. SS Elly De La Cruz went 2-for-3 with a run scored in a losing effort for the Reds (16-15), who fell to 7-8 at home. 

Cincinnati skipper Terry Francona will give the nod to talented southpaw Andrew Abbott (2-0 3.60 ERA) on Thursday. The Reds have won Abbott’s first three starts and he has struck out 20 batters across 15 frames.

Cincinnati OF Austin Hays is dealing with a hamstring injury and is listed as day-to-day. Through 30 games, St. Louis ranks 10th in OPS and 12th in runs scored. For the season, Cincinnati ranks 7th in OPS and 5th in runs scored. Take the Cardinals to win on the road. Final Score Prediction, St. Louis Cardinals win 6-3.