Cardinals vs White Sox Picks and Prediction – 6/19/2025

The Saint Louis Cardinals stay on the road Thursday afternoon with game one of a double header in Chicago against the White Sox. Saint Louis has 38 wins and 35 losses this season coming into this matchup having won two of the last three following a 10 run victory in Game 1 of this set. The Cardinals offense has a .257 team batting average and has scored 340 runs on 637 hits. The Saint Louis coaching has been solid all year with a 3.97 team ERA. Stay up to date with our MLB Picks.

Brendan Donovan leads the  Saint Louis offense  this season with a .323 batting average and 83 hits on the year. Lars Nootbar has a .223 batting average and Nolan Arenado has a .244 batting average. Willson Contreras has a .248 batting average and leads Saint Louis with nine home runs and 45 RBI's through 69 games played.

The Chicago White Sox stay on their home field Thursday is one of the worst teams in baseball 27 games under .500 riding a long losing streak. Offensively Chicago has been horrendous with a .222 team batting average. The White Sox have scored just 250 runs and 529 hits. The Chicago pitching has been horrendous as well with a 4.23 team ERA.

Miguel Vargas leads the Chicago offense this season with a .242 batting average, 10 home runs, and 31 RBIs. Luis Robert Jr. is second on the roster with 28 RBIs through 66 games played. Lenyn Sosa has a .275 batting average and Chase Meidroth has a .276 batting average this season. Omar Narvaez as a .286 batting average this season for Chicago but has played in just four games total. Edgar Quero has a .284 batting average for Chicago this season through 47 games played.

Chicago is one of the worst teams in the league and will continue to have their issues on Thursday. Take the Cardinals Thursday to do the work leading to the win on the road. St. Louis is the better team on both sides and will get it done in Chicago. Final Score Prediction, St. Louis Cardinals win 6-2.