Cardinals vs White Sox Picks and Prediction – 6/18/2025

On Wednesday, the St. Louis Cardinals (37-35) face off against the Chicago White Sox (23-49) at Rate Field in Chicago, Illinois. Keep up to date with all the MLB action, with our expert MLB picks.

St. Louis comes into this matchup on a one-game losing streak and has dropped four of their last five games prior to their series opener against Chicago. In their recent 3-2 loss against Milwaukee, Ivan Herrera put forth a solid effort for the Cardinals, going 2-for-3 at the plate with a home run, tallying both a run scored and an RBI. Looking at the team's season stats, Willson Contreras currently tops St. Louis in home runs with nine to his name. Trailing just behind him, Nolan Arenado, Ivan Herrera, and Lars Nootbaar have each contributed eight home runs so far, underscoring their importance in the team's offensive lineup. Contreras also leads the Cardinals in RBIs, having driven in forty-five runs this season—making him a key run producer. When it comes to batting average, Brendan Donovan stands out as St. Louis’ most consistent hitter, boasting a .313 batting average. Defensively, however, the Cardinals have hit a rough patch recently. Over their last five games, they've allowed an average of 4.4 runs per game, and they've now fallen seven games behind the Cubs in the NL Central standings. As they prepare to face the Chicago White Sox, improving their defense and regaining momentum has become a priority. On average, the Cardinals are putting up 4.6 runs per game this season, showing their lineup still has the ability to keep them competitive in most matchups.

Chicago enters this game on a five-game losing streak prior to their series opener against St. Louis. In their recent 2-1 defeat against Texas, Miguel Vargas was one of the few bright spots for the White Sox, going 1-for-4 at the plate. His only hit of the night was a solo home run, accounting for Chicago’s lone run and providing him with one RBI in that matchup. With that homer, Vargas now leads the team in long balls, reaching double digits with ten home runs on the season. Trailing him in the home run tally for Chicago are Andrew Benintendi and Luis Robert Jr., who have each connected for six home runs so far this year. When it comes to driving in runs, Vargas is also at the top of the leaderboard for the club, having racked up 31 RBIs—more than any other White Sox player this season. Vargas has not just been a power threat; he’s also posted the highest batting average on the squad, hitting at a .242 clip. Despite his individual success, the White Sox as a team have struggled lately, enduring a five-game losing streak during which they've surrendered an average of 4.8 runs per contest. Heading into their next matchup at home against St. Louis, Chicago will be aiming to turn things around, as they currently average just 3.4 runs scored per game across the season.

Both teams have hit a rough patch lately, coming into this matchup on the heels of several disappointing performances. The Cardinals are eager to bounce back and recapture the form that saw them enjoy success not too long ago. Meanwhile, the White Sox are determined to end their current losing streak and are hoping to notch a solid win against St. Louis. On the mound for the Cardinals is Sonny Gray, who has turned in a strong season so far with a 7-2 record and an ERA of 3.84. The White Sox will counter with Sean Burke, whose season has been more challenging—he holds a 3-7 record with a 4.71 ERA. Final Score Prediction, St. Louis Cardinals win 4-2.