Cardinals vs White Sox Picks and Prediction – 6/19/2025

The Saint Louis Cardinals stay on the road Thursday for a doubleheader in Chicago. Saint Louis comes into Thursday with 38 wins this season but have dropped three of the last five overall. The Saint Louis offense has been solid enough this season with 340 runs scored on 637 hits. The Saint Louis power has been mediocre with 68 home runs and a .393 team slugging percentage. Stay up to date with our MLB Picks.

Matthew Liberatore got the start and win for Saint Louis in Game 1 of this series giving up two runs on five hits across 6 innings of work. The Saint Louis bullpen shut the White Sox down, giving up no runs on one hit across the game’s final three innings. Offensively St. Louis rolled with 13 hits to score 12 runs overall. Ivan Herrera led the way for the Saint Louis offense with two hits and five at bats to drive in four total runs. Alec Burleson Chipped in three hits and five at bats to drive in two runs as well.

The Chicago White Sox stay at home Thursday as one of the worst teams in baseball riding a long losing streak. Offensively Chicago has been terrible with just 250 runs scored on 529 hits. The Chicago power has been nonexistent as well with only 55 home runs and .342 teams slugging percentage this season.

Vinny Capra got the start for Chicago in Game 1 of this series giving up two runs on two hits across one inning of work resulting in a no decision. Shane Smith came on in relief to give up six runs on six hits across 4.1 innings of work resulting in the loss. The rest of the Chicago bullpen gave up four runs on five hits over the final 3.2 innings of the game.

The Cardinals are the far better team in this game and it will show from early on. The Cardinals will overwhelm the White Sox from the jump. Take St. Louis to control this game as they get the sweep Wednesday with wins in both games. Final Score Prediction, St. Louis Cardinals win 7-1.