Cardinals vs White Sox Picks and Prediction – 6/17/2025

The St Louis Cardinals open a three-game series on the road Tuesday versus the Chicago White Sox. St Louis dropped to 37-35 following a 3-2 loss to the Milwaukee Brewers on Sunday. St Louis lost three out of four to Milwaukee, and the Cardinals have lost seven of the last eight. St Louis trails the first-place Chicago Cubs in the National League Central by seven games. Keep up to date with all the MLB action with our expert MLB picks.

Brendan Donovan is batting .313 with 79 hits and an on-base percentage of .381 to lead St Louis in the three categories. Willson Contreras leads in home runs with nine and in RBI with 45. St Louis is batting .255 with a .391 slugging percentage. On Tuesday, the St Louis Cardinals will send Matthew Liberatore to the mound. The left-hander is 3-6 with a 4.17 ERA, 62 Ks, and 11 BBs.

The Chicago White Sox dropped to 23-49 following Sunday’s 2-1 loss on the road to the Texas Rangers. Chicago was swept in its three-game series with Texas, and the White Sox have lost each of the last five. Chicago is 27th in runs scored and 21st in ERA. The White Sox are last in the American League Central, 22 ½ games behind the first-place Detroit Tigers.

Miguel Vargas is batting .242 with 10 home runs, 31 RBI, 61 hits, and an on-base percentage of .322 to lead Chicago in each of the five categories. Chicago has only one player with double-digit home runs. The White Sox are batting .222 with a .343 slugging percentage. On Tuesday, Chicago will send Shane Smith to the mound. The right-hander is 3-3 with a 2.37 ERA, 64 Ks, and 27 BBs.

St Louis has lost seven of its last eight, and the Cardinals have dropped four of the last five played on the road. St Louis starter Matthew Liberatore has struggled in each of the last three starts, allowing 16 runs on 24 hits across only 14 innings. Chicago starter Shane Smith has had two consecutive strong outings, allowing one run on 10 hits across 11.1 innings. Final Score Prediction: Chicago White Sox win 7-2.