Cardinals vs Cubs Picks and Prediction – 7/4/2025

Historic Wrigley Field will play host to a Friday afternoon MLB clash between the St. Louis Cardinals and the Chicago Cubs. Be ready for the baseball season with all of our MLB predictions. The Cardinals (47-41) are looking to rebound after failing to score a run during a three-game series loss in Pittsburgh. On Wednesday, St. Louis SP Sonny Gray (8-3) gave up four runs across six plus frames during a 5-0 road loss.  

Thirty-six year old righty Miles Mikolas (4-5 4.76 ERA) will take the mound for the Cardinals in this matchup. St. Louis has dropped three of Mikolas’ last four starts and he has surrendered 17 runs over his last 20 innings. 

The Chicago Cubs have won 28 of their first 43 home games and own the best run differential in the National League. Last night, Chicago walked it off in the tenth inning on a Matt Shaw sacrifice fly during a 1-0 home victory versus Cleveland. SP Cade Horton fired seven shutout frames and did not factor in the decision for the Cubs (52-35), who hold a 3.5 game lead for the top spot in the NL Central Division. 

Chicago skipper Craig Counsell will turn to veteran right-hander Colin Rea (5-3 4.37 ERA) on Friday. In his last start, Rea (5 IP) allowed five hits and two runs during a 12-3 road triumph against Houston. 

St. Louis 3B Nolan Arenado (finger) and 1B Willson Contreras (wrist) were held out of Wednesday’s lineup. Both are considered day-to-day. Through 88 games, St. Louis ranks 15th in OPS and 10th in runs scored. For the season, Chicago ranks 4th in OPS and 2nd in runs scored. Take the over. Final Score Prediction, Chicago Cubs win 7-5.