Cardinals vs Cubs Picks and Prediction – 7/6/2025

By: Cameron Ross |

Last Updated: 07/05/2025 at 8:23 PM ET

St. Louis Cardinals at Chicago Cubs 07/06/25 - MLB Picks & Predictions
Game Start: 7/6/2025, 10:10 PM UTC
Latest Odds: CHC -210 ; O/U 8.5

Cardinals vs Cubs Prediction

The Saint Louis Cardinals stay on the road Sunday with another game in Chicago against the Cubs. Saint Louis has 47 wins this season but coming into Sunday the Cardinals are riding a long losing streak following their loss in Game 1 of this series. Offensively St. Louis has a .253 batting average and the Cardinals have scored 403 runs on 754 hits. The Saint Louis pitching has been solid enough this season with a 3.94 team ERA, but the Cardinals gave up eleven runs in Game 1 of this series. Stay in the action with our MLB Picks.

Brendan Donovan leads the St. Louis offense this season with a .293 batting average and 92 hits on the year. Lars Nootbar has a .227 batting average and Nolan Arenado has a .244 batting average. Willson Contreras has a .246 batting average and leads Saint Louis with eleven home runs and 51 RBIs this season.

The Chicago Cubs stay on their home field Sunday with 53 wins this season riding a  lengthy winning streak after their winning of game 1 of this series. Offensively Chicago has been solid all season with a .255 batting average the Cubs have scored 464 runs on 767 hits. The Chicago power has been outstanding this season with 125 total home runs and a .442 team slugging percentage.

Michael Busch leads the Chicago offense this season with an .288 batting average through 82 games played. Pete Crow-Armstrong has been fantastic for Chicago as well this season with a .274 batting average and 23 home runs on the year. Seiya Suzuki leads the team with 24 home runs and 74 RBIs through 84 games played. Kyle Tucker has come up huge for Chicago all season with a .284 batting average and leads the team with a .388 OBP and 93 hits this season.

Cardinals vs Cubs Pick Analysis

The Cubs are the better team with the better arm on the mound and will continue to roll in this game. Look for Chicago to do the work on both sides leading to another win against divisional foe. Take Chicago Sunday to end the weekend with a win at home. Final Score Prediction, Chicago Cubs win 6-2.

Our Free MLB Pick for Chicago Cubs vs St. Louis Cardinals

Chicago Cubs -210