Cardinals vs Cubs Picks and Prediction – 7/5/2025

NL Central Division rivals will clash on Saturday afternoon, when the St. Louis Cardinals and the Chicago Cubs from Wrigley Field. Be ready for the baseball season with all of our MLB predictions. The Cardinals (47-42) are looking to snap a four-game losing streak and are 6.5 games out of first place. On Friday, St. Louis SP Miles Mikolas (4-6) was knocked around for ten hits and eight runs in six innings during an 11-3 road loss against Chicago. 

Twenty-five year old southpaw Matthew Liberatore (6-6 3.70 ERA) will head to the hill for the Cardinals in this contest. St. Louis has won Liberatore’s last three starts and he has allowed four runs over his last 19 innings. 

The Chicago Cubs have reeled off four straight victories and hold a 4.5 game lead over Milwaukee for the top spot in the division. 1B Michael Busch crushed three of Chicago’s franchise record eight home runs and raised his average to .288 on the year. OF Pete Crow-Armstrong went deep twice and scored four times for the Cubs (53-35), who improved to 29-15 at home. 

Chicago skipper Craig Counsell will be forced to go with a bullpen game on Saturday. The Cubs rank in the middle of the pack with a 3.78 ERA and have struck out 738 batters across 777 plus frames.

Chicago SP Jameson Taillon has been placed on the 15-day injured list with a right calf strain. Through 89 games, St. Louis ranks 15th in OPS and 10th in runs scored. For the season, Chicago ranks 4th in OPS and 2nd in runs scored. Take the over. Final Score Prediction, Chicago Cubs win 8-6.