Cardinals vs Red Sox Picks and Prediction – 4/5/2025

By: Cameron Ross |

Last Updated: 04/04/2025 at 7:37 PM ET

St. Louis Cardinals at Boston Red Sox 04/05/25 - MLB Picks & Predictions
Game Start: 4/5/2025, 8:10 PM UTC
Latest Odds: BOS -125 ; O/U 9

Cardinals vs Red Sox Prediction

The Saint Louis Cardinals stay on the road Saturday with Game 2 of three in Boston against the Boston Red Sox. Saint Louis has four wins and two losses on the year following a 7 run victory against Los Angeles in their last outing to end a 2 game losing streak. Offensively St. Louis has been good enough this season with a .298 team batting average having compiled 64 hits to score 42 total. The Saint Louis pitching has been solid as well with a 3.47 team ERA. For other MLB action see our MLB Picks.

Lars Nootbaar leads the Saint Louis offense this season with a .417 batting average. Nolan Arenado has a .391 batting average and Victor Scott II has come up big this season with a .348 batting average. IvanHerrera leads Saint Louis this season with three home runs and eight RBI's despite playing just five games this season.

The Boston Red Sox return home for this series with three wins and four losses on the year riding a 2 game-winning streak after a four run victory on the road against Baltimore appeared offensively Boston is a bottom feeder in the league with a .217 batting average as the Red Sox have scored just nineteen runs on 44 hits. The Boston power has been lackluster as well with just four home runs and he .330 team slugging percentage.

WIlyer Abreu is the offensive leader this  season for Boston with a .471 batting average two home runs and six RBI's. Kristian Campbell has been phenomenal this season as well with a .417 batting average. Alex Bregman has a .290 batting average and Rob Refsnyder is hitting .667 on the year but has played in just 1 game.

Cardinals vs Red Sox Pick Analysis

The Cardinals are having the better year and will keep it going in this game. Look for St. Louis to do the work as the Boston offense is so shaky. Take St. Louis to do the work Saturday on the road leading to the win against an AL opponent. Final Score Prediction, St. Louis Cardinals win 7-4.

Our Free MLB Pick for Boston Red Sox vs St. Louis Cardinals

St. Louis Cardinals +105