Cardinals vs Red Sox Picks and Prediction – 4/4/2025

The St. Louis Cardinals open a three-game series on the road at Fenway Park on Friday versus the Boston Red Sox. St Louis is 4-2 and first in the National League Central, a half-game ahead of the Chicago Cubs. St Louis defeated the Los Angeles Angels 12-5 on Wednesday, snapping a two-game losing streak. St. Louis will complete a three-game series with LA on Thursday. Keep up to date with all the MLB action with our MLB picks.

Lars Nootbaar is batting .417 with 10 hits and a .533 on-base percentage to lead St. Louis in each of the three categories. Ivan Herrera is the leader in home runs with three and RBI with eight. St Louis has a team batting average of .298 and a slugging percentage of .498. On Friday, St. Louis will send Erick Fedde to the mound. The right-hander is 1-0 with a 1.50 ERA, 2 Ks, and 0 BBs. 

The Boston Red Sox are 2-4 following a 3-0 victory over the Baltimore Orioles on Wednesday, snapping a four-game losing streak. Garrett Crochet threw eight strong innings for Boston in the first to start following his signing of a big contract with the Bosox. Boston had opened the season with a victory and then lost four straight before Wednesday’s win. 

Wilyer Abreu is batting .500 with two home runs, six RBI, and an on-base percentage at .650 to lead Boston in each of the four categories. Kristian Campbell is the leader in hits with eight. Boston has a team batting average of .217 and a slugging percentage of .330. On Friday, Boston will send Walker Buehler to the mound. The right-hander is 0-1 with an 8.31 ERA, 3 Ks, and 0 BBs.

St Louis has won 10 of its last 14, while Boston has lost four of its last six. The Cardinals have won four of the first six this season. St Louis starter Erick Fedde gave up one run on two hits across six innings last Saturday. Boston starter Walker Bueller was hit hard in his first outing, allowing four runs on seven hits in just 4.1 innings. Final Score Prediction, St. Louis Cardinals win 5-2.