Cardinals vs Orioles Picks and Prediction – 5/27/2025

Beautiful Camden Yards will play host to a Tuesday night MLB interleague clash between the St. Louis Cardinals and the Baltimore Orioles. Be ready for the baseball season with all of our MLB predictions. The Cardinals (30-24) are five games below .500 on the road and trail NL Central Division leading Chicago by three games. On Monday, St. Louis managed just four hits and committed a pair of errors during a 5-2 road loss against Baltimore. 

Twenty-six year old righty Andre Pallante (4-3 4.18 ERA) will take the mound for the Cardinals in this matchup. Last time out, Pallante (5.2 IP) gave up four hits and three runs during a 5-1 home loss versus Detroit. 

The Baltimore Orioles have won three straight games and are attempting to climb out of the AL East Division cellar. During yesterday’s home victory, Baltimore OF Dylan Carlson put the game out of reach with a fourth inning three-run blast. Veteran SP Charlie Morton (1-7) allowed two runs across six solid frames to earn the win for the Orioles (19-34), who improved to 9-15 at home. 

Thirty-five year old righty Tomoyuki Sugano (4-3 3.07 ERA) has been the lone reliable option in the Baltimore rotation. In his last start, Sugano (6 IP) allowed five hits and two runs during an 8-4 road victory against Milwaukee. 

St. Louis 3B Nolan Arenado was held out of Monday’s lineup with rib soreness and is listed as day-to-day. Through 54 games, St. Louis ranks 10th in OPS and 8th in runs scored. For the season, Baltimore ranks 22nd in OPS and 25th in runs scored. Take the Cardinals to win on the road. Final Score Prediction, St. Louis Cardinals win 6-3.