Mariners vs Padres Picks and Prediction – 5/17/2025

This Friday, Logan Evans and the Seattle Mariners head to Petco Park to take on Stephen Kolek and the San Diego Padres in an interleague showdown. Get our free MLB Picks all season long! The Mariners, now 23-19, are coming off a narrow 3-2 loss to the Yankees on Wednesday and will look to get back on track with better offensive execution.

Evans will be making a key appearance as Seattle looks to build consistency in its rotation. He’ll need to navigate a Padres lineup that’s been producing at a high level, especially in the middle of the order. Command and minimizing free passes will be critical for his outing.

The Padres, now 27-15, enter this game following a solid 5-1 win over the Angels. Kolek takes the mound again after a quality showing in his last outing. He’s provided needed depth for San Diego’s pitching staff and will aim to keep momentum going against a Mariners offense that has struggled in big moments.

Seattle’s path to victory depends on their ability to generate early pressure on Kolek and provide Evans with a cushion. San Diego will look to strike early and ride their bullpen if needed, as both clubs seek to set the tone in this weekend series.

With San Diego’s lineup producing and Kolek delivering steady performances, the Padres hold the upper hand at home. Seattle will compete, but unless Evans shines, San Diego should come out on top. Take the Padres to win this one and to cover the run line. Final Score Prediction, San Diego Padres win 5-3