Mariners vs Twins Picks and Prediction – 6/25/2025

Seattle (40–37) heads into a four-game weekend set in Minnesota (37–41) under the summer gloom of Target Field. This midweek matchup features rookie right-hander George Kirby for the Mariners (1–3, 6.16 ERA) and rising talent Joe Ryan for the Twins (7–3, 2.91 ERA). Both teams are navigating slumps and surges, creating a compelling storyline as they clash tonight. Get in on all the baseball action with our free MLB picks.

The Mariners rallied with a series win over Chicago but remain inconsistent on the road. Kirby, making his 10th start, dazzled on June 8 with 14 Ks in seven shutout innings but has struggled since, carrying a bloated ERA. Still, his strikeout potential and groundball tendencies can keep opposing lineups in check. Offensively, Cal Raleigh (32 HR) and Jorge Polanco (AL Player of the Week) bring power, but the team still leans on pitching to win close games. 

Twins Ace Joe Ryan continues to anchor the rotation with a 2.91 ERA over 12 starts. His recent outings include a solid seven-inning, two-ER performance against Houston. Minnesota’s offense has cooled after a rough stretch, though Byron Buxton remains a bright spot. The defense has been shaky, with recent lapses that contributed to their 1–3 skid, but improved run support could aid Ryan tonight, as the Twins have a streaky offensive unit.

Expect a well-pitched contest early, with Ryan’s command against Kirby’s swing-and-miss stuff. Minnesota’s offense could break through late, and we like Byron Buxton to start the rally for the Twins. With all that in mind, we say take the Minnesota Twins to win a thrilling matchup, by a score of 5-3.