Mariners vs Astros Picks and Prediction – 5/25/2025

The Seattle Mariners play the final game of a four-game series on the road Sunday versus 13 Houston Astros. Seattle improved to 29-21 following Friday’s 5-3 win over Houston in the second game of the series. Seattle has won two of the last three and is first in the American League West, 3 ½ games ahead of the second-place Astros. Keep up to date with all the MLB action with our expert MLB picks.

J.P. Crawford is batting .266 to lead Seattle and has a team-high .386 on-base percentage. Cal Raleigh is the leader in home runs with 17, RBI with 35, and hits with 47. Seattle is batting .237 with a .402 slugging percentage. On Sunday, the Seattle Mariners will send Luis Castillo to the mound. The right-hander is 4-3 with a 3.20 ERA, 44 Ks, and 20 BBs.

The Houston Astros dropped to 26-25 following Friday’s two-run loss to Seattle. Houston has lost three of the last four. The Astros are just 17th in runs scored and 21st in slugging percentage. Houston has remained close to first in the AL West thanks to strong pitching with a 3.48 ERA (9th). The Astros are 3 ½ games behind the first-place Mariners. 

Jake Meyers is batting .309 to lead Houston, while Jeremy Pena is the leader in hits with 56. Isaac Paredes is leading Houston in home runs with 11, RBI with 31, and on-base percentage at .374. Houston is batting .250 with a .383 slugging percentage. On Sunday, Houston will send Colton Gordon to the mound. The left-hander is 0-0 with a 5.59 ERA, 10 Ks, and 2 BBs.

Seattle has won six of its last eight, and the Mariners have won six of the last nine head-to-head versus Houston. On the road, Seattle has won eight of its last 10. Seattle starter Luis Castillo has had two consecutive strong outings, allowing one run on nine hits across 13 innings. Houston starter Colton Gordon has been hit hard in two consecutive outings, allowing six runs on 12 hits across 9.2 innings. Final Score Prediction: Seattle Mariners win 6-2.