Mariners vs Astros Picks and Prediction – 5/24/2025

By: David Anicetti |

Last Updated: 05/23/2025 at 8:39 PM ET

Seattle Mariners at Houston Astros 05/24/25 - MLB Picks & Predictions
Game Start: 5/24/2025, 8:10 PM UTC
Latest Odds: HOU -120 ; O/U 7.5

Mariners vs Astros Prediction

The Seattle Mariners play the third game of a four-game series on the road Saturday versus the Houston Astros. Seattle dropped to 28-21 following Thursday’s 9-2 loss to Houston in the opening game of the series. Seattle has lost two out of the last three but remains first in the American League West, 2 ½ games ahead of the second-place Astros. Keep up to date with all the MLB action with our expert MLB picks.

J.P. Crawford is batting .262 to lead Seattle and has a team-high .386 on-base percentage. Cal Raleigh is the leader in home runs with 16 and RBI with 33, while Julio Rodriguez is the leader in hits with 45. Seattle is batting .236 with a .398 slugging percentage. On Saturday, Seattle will send Bryan Woo to the mound. The right-hander is 5-1 with a 2.65 ERA, 55 Ks, and 8 BBs.

The Houston Astros improved to 26-24 following Thursday’s seven-run victory over Seattle. Jose Altuve hit a pair of home runs and knocked in four runs. Jeremy Pena hit a triple to help lead the Astros to the win. Houston snapped a two-game losing streak with Thursday’s win, and as mentioned previously, has cut Seattle’s lead in the AL West to 2 ½ games.

Jake Meyers is batting .304 to lead Houston, while Jeremy Pena is the leader in hits with 56. Isaac Paredes is leading Houston in home runs with 10, RBI with 29, and on-base percentage at .374. Houston is batting .249 with a .383 slugging percentage. On Saturday, the Houston Astros will send Framber Valdez to the mound. The left-hander is 3-4 with a 3.57 ERA, 59 Ks, and 19 BBs.

Mariners vs Astros Pick Analysis

Seattle will win on the road Saturday when visiting Houston, but the play here is UNDER. The UNDER has cashed in seven of Seattle's last nine and seven of Houston's last 10. Seattle starter Bryan Woo has had two straight strong outings, allowing one run on nine hits across 13-1 innings. Houston starter Framber Valdez has pitched well in three straight outings, allowing five runs on 15 hits across 22 innings. Final Score Prediction: Seattle Mariners win but our best play is UNDER 4-2.

Our Free MLB Pick for Houston Astros vs Seattle Mariners

Under 7.5