Mariners vs Reds Picks and Prediction – 4/16/2025

The Seattle Mariners play the second game of a three-game series on the road Wednesday versus the Cincinnati Reds. Seattle improved to 8-8 following its 3-1 victory over the Texas Rangers on Sunday. Seattle swept Texas in a three-game series, and the Mariners have won each of the last four. Seattle is third in the American League West, 1 ½ games behind the first-place Los Angeles Angels. Keep up to date with all the MLB action with our MLB picks.

Jorge Polanco is batting .378 to lead Seattle and leads the Mariners in RBI with 12 and hits with 14. Cal Raleigh is the leader in home runs with five, and J.P. Crawford is the leader in on-base percentage with .357. Seattle is batting .210 with a .359 slugging percentage. On Wednesday, Seattle will send Bryce Miller to the mound. The right-hander is 0-2 with a 4.50 ERA, 13 Ks, and 8 BBs.

The Cincinnati Reds improved to 8-8 following Sunday’s 4-0 victory over the Pittsburgh Pirates. Hunter Greene pitched seven shutout innings for the Reds in Sunday’s win, which completed a three-game sweep of the Pirates. Cincinnati has won five of the last six and trails first-place in the National League Central by just 1 ½ games.

TJ Freidl is batting .254 with 15 hits to lead Cincinnati in both statistics. Matt McLean is the leader in home runs with three, and Elly De La Cruz is the leader in RBI with 17. Gavin Lux has a team-best .322 on-base percentage. On Wednesday, the Cincinnati Reds will send Nick Martinez to the mound. The right-hander is 0-2 with a 6.06 ERA, 15 Ks, and 4 BBs.

Seattle has won five of its last six, and the Mariners have won nine of the last 12 head-to-head versus the Reds. Seattle starter Bryce Miller is coming off a solid outing in which the right-hander allowed one run on two hits across five innings to beat Texas. Cincinnati starter Nick Martinez has been hit hard in three consecutive outings, allowing 11 runs across 16.1 innings. Final Score Prediction: Seattle Mariners win 6-3.