Mariners vs White Sox Picks and Prediction – 5/21/2025

The Seattle Mariners complete a three-game series on the road Wednesday versus the Chicago White Sox. Seattle improved to 27-19 following its 5-1 victory on Monday over the White Sox in the opening game series. Julio Rodriguez belted a grand slam for the Mariners, and Luis Castillo threw seven strong innings. Seattle leads the American League West by 2 ½ games over the Houston Astros. Keep up to date with all the MLB action with our MLB predictions.

J.P. Crawford is batting .271 with an on-base percentage of .383 to lead Seattle in both categories. Cal Raleigh is the leader in home runs with 15 and RBI with 32, while Julio Rodriguez is the leader in hits with 44. Seattle is batting .238 with a .400 slugging percentage. On Wednesday, Seattle will send Logan Evans to the mound. The right-hander is 2-1 with a 2.57 ERA, 14 Ks, and 8 BBs.

The Chicago White Sox dropped to 14-34 following Monday’s four-run loss to the Seattle Mariners. Chicago is 28th in runs scored and 30th in team batting average, while on the mound, the White Sox are 21st in ERA. Chicago has lost five straight. Chicago is last in the American League Central, 17 games behind the first-place Detroit Tigers.

Lenyn Sosa is batting .265 with 41 hits to lead Chicago in both categories. Miguel Vargas is the leader in home runs with six, RBI with 21, and on-base percentage a .321. Chicago is batting .216 with a .328 slugging percentage. On Wednesday, the Chicago White Sox will send Shane Smith to the mound. The right-hander is 1-3 with a 2.05 ERA, 43 Ks, and 16 BBs.

Chicago will beat Seattle on Wednesday, but the play here is UNDER. The UNDER has cashed in each of Seattle's last six and six of Chicago's last 9. Seattle starter Logan Evans has had four consecutive solid outings, allowing six runs on 24 hits across 21 innings. Chicago starter Shane Smith has had five consecutive strong outings, allowing four runs on 26 hits across 26 innings. Final Score Prediction: Chicago White Sox win but our best play is UNDER 4-2.