Mariners vs White Sox Picks and Prediction – 5/20/2025

By: Cameron Ross |

Last Updated: 05/19/2025 at 11:28 PM ET

Seattle Mariners at Chicago White Sox 05/20/25 - MLB Picks & Predictions
Game Start: 5/20/2025, 11:40 PM UTC
Latest Odds: SEA -175 ; O/U 8.5

Mariners vs White Sox Prediction

The Seattle Mariners will be on the road Tuesday night with a game in Chicago against the Chicago White Sox. Seattle comes into this game with 26 wins and 19 losses on the year having won for the last five including three in a row after a sweep of the San Diego Padres over the weekend. Offensively Seattle has been mediocre this season with a .238 team batting average as the Mariners have scored 216 runs on 360 three hits. The Seattle pitching has carried the load for the team this year with a 3.72 team ERA. Stay in the action with our MLB Picks.

JP Crawford leads the Seattle offense this season with a .270 batting average. Julio Rodriguez has a .235 batting average but leads Seattle with 43 hits this season. Cal Raleigh supplies the power for the Mariners with 15 home runs and 30 two RBI's on the year.

The Chicago White Sox return home Tuesday night as one of the worst teams in baseball 19 games below .500 having lost four straight games. Offensively Chicago is terrible with a .217 batting average as the White Sox scores 157 runs on 330 hits. The Chicago pitching has failed them as well this season with a 4.23 team ERA.

Lenyn Sosa leads the Chicago White Sox offense this season with a .265 batting average and 41 hits on the year. Korey Lee Has a .333 batting average for Chicago this year but has played in only nine games. Miguel Vargas has been vital for Chicago this season with a .245 batting average to go along with the team leading six home runs and 21 RBIs on the year.  Luis Robert Jr. has five home runs and 17 RBIs this season despite a .184 batting average.

Mariners vs White Sox Pick Analysis

Seattle is the far better team in this game and it will show from the opening pitch Tuesday night. Chicago will put a winless pitcher on the mound with a ballooned ERA that will spark the Seattle bats. Take the Mariners Tuesday to do the job leading to the road win in Chicago. Final Score Prediction, Seattle Mariners win and cover 8-1.

Our Free MLB Pick for Chicago White Sox vs Seattle Mariners

Seattle Mariners -175