Mariners vs White Sox Picks and Prediction – 5/19/2025

By: David Anicetti |

Last Updated: 05/18/2025 at 9:11 PM ET

Seattle Mariners at Chicago White Sox 05/19/25 - MLB Picks & Predictions
Game Start: 5/19/2025, 11:40 PM UTC
Latest Odds: SEA -210 ; O/U 8

Mariners vs White Sox Prediction

The Seattle Mariners open a three-game series on the road Monday versus the Chicago White Sox. Seattle improved to 25-19 following its 4-1 victory over the San Diego Padres on Saturday. Cal Raleigh hit his 15th home run of the season for Seattle. The Mariners have won two straight and three of the last four. Seattle is first in the American League West, 1 ½ games ahead of the Texas Rangers. Keep up to date with all the MLB action with our MLB predictions.

J.P. Crawford is batting .270 to lead Seattle, and Julio Rodriguez is the leader in hits with 42. Cal Raleigh is the leader in home runs with 15 and in RBI with 31. Randy Arozarena is the leader in on-base percentage with .385. On Monday, the Seattle Mariners will send Luis Castillo to the mound. The right-hander is 3-3 with a 3.65 ERA, 39 Ks, and 20 BBs.

The Chicago White Sox dropped to 14-32 following Saturday’s 7-3 loss to the Chicago Cubs. The White Sox have lost each of the first two games of their three-game Crosstown Classic with the Cubs. Chicago has lost three straight and eight of the last 12. The White Sox are last in the American League Central, 16 games behind the first-place Detroit Tigers.

Lenya Sosa is batting .261 to lead Chicago and has a team high of 40 hits. Andrew Benintendi is the leader in home runs with five. Miguel Vargas is the leader in RBI with 20 and in on-base percentage with .318. Chicago is batting .216 with a .330 slugging percentage. On Monday, Chicago will send Davis Martin to the mound. The right-hander is 2-4 with a 3.65 ERA, 33 Ks, and 12 BBs.

Mariners vs White Sox Pick Analysis

Chicago will win at home on Monday when hosting Seattle but the play here is UNDER. The UNDER has cashed in four of Seattle's last five and five of Chicago's last seven. Seattle Mariners starter Luis Castillo is coming off a strong outing in which the right-hander allowed one run on six hits across six innings. Chicago starter Davis Martin is coming off a strong outing in which the right-hander allowed one run across 6.2 innings. Final Score Prediction: Chicago White Sox win but our best play is UNDER 4-2.

Our Free MLB Pick for Chicago White Sox vs Seattle Mariners

Under 8