Mariners vs Cubs Picks and Prediction – 6/21/2025

The Seattle Mariners play the second game of a three-game series on the road Saturday versus the Chicago Cubs. Seattle dropped to 37-36 following its 3-1 loss at home to the Boston Red Sox on Wednesday. Seattle lost two out of three to Boston, and the Mariners were off on Thursday. Seattle trails first-place Houston in the American League West by five games. Keep up to date with all the MLB action with our expert MLB picks.

J.P. Crawford is batting .294 with an on-base percentage of .416 to lead Seattle in both categories. Cal Raleigh leads in home runs with 27 and RBI was 60, while Julio Rodriguez is the leader in hits with 75. Seattle is batting .242 with a .394 slugging percentage. On Saturday, Seattle will send Emerson Hancock to the mound. The right-hander is 3-2 with a 4.48 ERA, 45 Ks, and 21 BBs.

The Chicago Cubs dropped to 45-29 following Thursday’s 8-7 loss to the Milwaukee Brewers. Pete Crow-Armstrong homered for the Cubs, his 20th of the season, but the Chicago pitching staff was hit hard. The loss snapped a three-game winning streak by the Cubs. Chicago leads the National League Central by 5 ½ games over Milwaukee and St Louis.

Nico Hoerner is batting .288 with 78 hits to lead Chicago in both categories. Pete Crow-Armstrong leads in home runs with 20, and Seiya Suzuki leads in RBI with 61, while Kyle Tucker is the leader in on-base percentage at .391. On Saturday, the Chicago Cubs will send Cade Horton to the mound. The right-hander is 3-1 with a 3.47 ERA, 29 Ks, and 8 BBs.

Chicago will win at home on Saturday when hosting Seattle, but the play here is UNDER. The UNDER has cashed in three of Seattle's last four, in five of Chicago's last six, and in seven of Seattle's last eight versus Chicago. Seattle starter Emerson Hancock has performed well in each of the last four outings, allowing five runs across 23 innings. Chicago starter Cade Horton is coming off a strong outing in which the right-hander allowed no runs on three hits across 5.2 innings. Final Score Prediction: Chicago Cubs win but our best play is UNDER 4-2.