Mariners vs Cubs Picks and Prediction – 6/20/2025

The Friday MLB schedule will get underway with a matinee between the Seattle Mariners and the Chicago Cubs from Wrigley Field. Be ready for the baseball season with all of our MLB predictions. The Mariners (37-36) have split their first 34 road games and trail AL West Division leading Chicago by 5.5 games. On Wednesday, Seattle batters managed just six hits and were retired by strikes ten times during a 3-1 home loss versus Boston. 

Twenty-seven year old righty George Kirby (1-3 5.96 ERA) will make his sixth start of the year for the Mariners. Through 25 plus innings, Kirby has struck out 30 batters and owns a 1.36 WHIP.

The Chicago Cubs have won 24 of their first 37 home games and hold a 5.5 game cushion for the top spot in the NL Central Division. On Thursday, Chicago SP Jameson Taillon (7-4) was rocked for five runs in four innings during an 8-7 home loss versus Milwaukee. Ian Happ, Pete Crow-Armstong, and Dansby Swanson all homered in a losing effort for the Cubs (45-29).

Rookie right-hander Cade Horton (3-1 3.47 ERA) will make his seventh career major league start for the Cubs. Last time out, Horton fired five plus shutout frames during a 2-1 home loss versus Pittsburgh. 

Chicago SP Shota Imanaga (hamstring) will make his third rehab start on Friday and should rejoin the rotation next week. Through 73 games, Seattle ranks 15th in OPS and 14th in runs scored. For the season, Chicago ranks 4th in OPS and 2nd in runs scored. Take the Cubs to win at home. Final Score Prediction, Chicago Cubs win 6-3.