Mariners vs Red Sox Picks and Prediction – 4/22/2025

The Seattle Mariners open a three-game series on the road Tuesday at Fenway Park versus the Boston Red Sox. Seattle is 12-10 following its 8-3 victory over the Toronto Blue Jays on Sunday. Cal Raleigh and Rowdy Tellez each had two-run home runs for the Mariners. Seattle is second in the American League West, one game behind the first-place Texas Rangers. Keep up to date with all the MLB action with our expert MLB picks.

Jorge Polanco is batting .346 to lead Seattle. Cal Raleigh is the leader in home runs with 9 and hits with 20. Randy Arozarena is the leader in RBI with 17, and J.P. Crawford leads in on-base percentage with .377. Seattle is batting .222 with a .393 slugging percentage. On Tuesday, the Mariners will send Bryce Miller to the mound. The right-hander is 1-2 with a 3.43 ERA, 21 Ks, and 10 BBs.

The Boston Red Sox dropped to 12-11 following Sunday’s 8-4 loss to the Chicago White Sox, snapping a four-game winning streak by Boston. Boston won each of the first two games of its series with the White Sox before losing on Sunday. Boston completes its series with Chicago on Monday. The Red Sox are third in the American League East, 2 ½ games behind the first-place New York Yankees.

Trevor Story is batting .318 with five home runs and 27 hits to lead Boston in the three categories. Alex Bregman is the leader in RBI with 16, and Wilyer Abreu is the leader in on-base percentage with .405. Boston is batting .246 with a .394 slugging percentage. On Tuesday, Boston will send Sean Newcomb to the mound. The left-hander is 0-2 with a 3.63 ERA, 19 Ks, and 9 BBs.

Boston will win at home on Tuesday when hosting Seattle, but the play here is UNDER. The UNDER has cashed in four of Boston's last six at home. Seattle starter Bryce Miller has had two consecutive strong outings, allowing one run on five hits across 10 innings. Boston starter Sean Newcomb has had three consecutive strong outings, allowing three runs on 16 hits across 13.1 innings. Final Score Prediction: Boston Red Sox win but our best play is UNDER 4-2.