Giants vs Nationals Picks and Prediction – 5/23/2025

In Friday night MLB action, the San Francisco Giants will invade the nation’s capital to take on the Washington Nationals. Be ready for the baseball season with all of our MLB predictions. The Giants (29-21) have split their first 24 road games and are two games behind NL West Division leading Los Angeles. On Wednesday, San Francisco batters went 0-for-7 with runners in scoring position and left ten men on base during an 8-4 home loss versus Kansas City. 

Twenty-six year old righty Lander Roupp (2-3 4.11 ERA) will make his tenth start of the year for the Giants. Last time out, Roupp (6 IP) scattered five hits and fanned six batters during a 1-0 home victory versus the Athletics. 

The Washington Nationals are riding a five-game winning streak and are sitting in fourth place in the competitive NL East Division standings. Last night, pinch-hitter Amed Rosario came through with a walk-off single in the tenth inning to lift Washington to an 8-7 home victory versus Atlanta. OF James Wood went 2-for-3 with three RBIs and a pair of runs scored for the Nationals (23-27).

Washington manager Dave Martinez will give the nod to talented southpaw MacKenzie Gore (2-4 3.67 ERA) in the series opener. Through 56 plus innings, Gore has struck out an impressive 84 batters and owns a 1.30 WHIP.

Washington OF Dylan Crews has been placed on the 10-day injured list with a lower back injury. Through 50 games, San Francisco ranks 17th in OPS and 9th in runs scored. For the season, Washington ranks 16th in OPS and 13th in runs scored. Take the Nationals to win at home. Final Score Prediction, Washington Nationals win 6-3.