Giants vs Padres Picks and Prediction – 4/30/2025

By: Cameron Ross |

Last Updated: 04/28/2025 at 9:12 PM ET

San Francisco Giants at San Diego Padres 04/29/25 - MLB Picks & Predictions
Game Start: 4/30/2025, 1:40 AM UTC
Latest Odds: SFG -129 ; O/U 6.7

Giants vs Padres Prediction

The San Francisco Giants will take a short road trip Tuesday night with a game in San Diego against the Padres. San Francisco has nineteen wins and 10 losses on the year having won four of the last five including two in a row after consecutive one run victories against the Texas Rangers. Offensively San Francisco has a .229 batting average having scored 135 runs on 220 hits. The San Francisco pitching has been solid as well with a 3.40 team ERA. Staying in the action with our MLB Picks.

Jung Hoo Lee leads the San Francisco office this season with a .324 batting average. Tyler Fitzgerald has a .289 batting average and David Villar has a .286 batting average but has played just twice this season. Wilmer Flores leads San Francisco with seven home runs and 28 RBIs this year.

The San Diego Padres remain at home Tuesday with 17 wins and 11 losses overall having lost 4 consecutive games after a three-game sweep against Tampa Bay. Offensively San Francisco has been solid this season with a .255 batting average the Padres have scored 100 and six runs on 231 hits. The Padres pitching is one of the best in baseball with a 2.82 team ERA.

Fernando Tatis Jr. is the offensive leader this season for San Diego with a .346 batting average to go along with the team leading eight home runs and eighteen RBI's. Manny Machado has a .272 batting average and Luis Arraez has a .287 batting average but has played in just 22 games. Jackson Merrill has a .378 batting average for San Diego this season but has played just 10 times this year. Gavin Sheets has a .275 batting average and twelve RBI's in 26 games played.

Giants vs Padres Pick Analysis

The Padres have hit a rough patch as of late and will look to get back on track in this game. The Padres will be at home with the better pitcher on the mound and that will help them Tuesday. The Padres as a team have a much higher batting average and a stronger team ERA that will carry them Tuesday. Final Score Prediction, San Diego Padres win 6-3.

Our Free MLB Pick for San Diego Padres vs San Francisco Giants

San Diego Padres +110