Giants vs Yankees Picks and Prediction – 4/12/2025

FS1 will feature a Saturday afternoon MLB interleague showdown between the San Francisco Giants and the New York Yankees from the Bronx. Be ready for the baseball season with all of our MLB predictions.The Giants (10-3) have won six of their first seven road games and are tied with Los Angeles for first place in the NL West Division. Last night, Jung Hoo Lee connected on a three-run blast in the first inning to lead San Francisco to a 9-1 road triumph against New York. 

Hard-throwing righty Jordan Hicks (1-0 2.38 ERA) is off to a fantastic start to his 2025 campaign. The Giants have won Hicks’ first two starts and he has struck out 11 batters through 11 plus innings. 

The New York Yankees are a game above .500 at home and trail Toronto by a half-game for the top spot in the AL East Division. During Friday’s series opener, New York batters managed just two hits and struck out nine times in the six-inning rain shortened affair. SP Marcus Stroman (0-1) was tagged for five runs and was unable to get out of the first innings in a losing effort for the Yankees. 

New York manager Aaron Boone will turn to twenty-five year old righty Will Warren (0-0 6.00 ERA) on Saturday. In his last start, Warren (4 IP) gave up six hits and four runs during a 5-4 road loss against Pittsburgh. 

New York DH Giancarlo Stanton (elbow) has been taking swings indoors and is expected to return to the lineup in early June. Through 13 games, San Francisco ranked 15th in OPS and 10th in runs scored. For the regular season, New York ranked 1st in OPS and 2nd in runs scored. Take the Giants to win on the road. Final Score Prediction, San Francisco Giants win 5-3.