Giants vs Yankees Picks and Prediction – 4/11/2025

The San Francisco Giants open a road trip on the East Coast with the first game of a three-game series on Friday versus the New York Yankees. San Francisco is 9-3 and second in the National League West, just a half-game behind the San Diego Padres. San Francisco defeated the Cincinnati Reds 8-6 on Wednesday, snapping a two-game losing streak and avoiding a three-game sweep in that series. Keep up to date with all the MLB action with our MLB previews.

Mike Yastrzemski is batting .344 with an on-base percentage of .462 to lead San Francisco in both categories. Wilmer Flores is the leader in home runs with five and RBI with 14, while Jung Hoo Lee is the leader in hits with 15. San Francisco has a team batting average of .228 and a slugging percentage of .404. On Friday, the Giants will send Robbie Ray to the mound. The left-hander is 2-0 with a 3.18 ERA, 6 Ks, and 6 BBs.

The New York Yankees improved to 7-5 following a 4-3 victory over the Detroit Tigers on Wednesday, avoiding a three sweep after losing the first two games of the series. New York is second in the American League East, a half game behind the Toronto Blue Jays. New York’s Max Fried outdueled high school teammate Jack Flaherty to help lead the Yankees to Wednesday’s win. 

Paul Goldschmidt is batting .383 to lead New York and has a team-high 18 hits. Aaron Judge is the leader in home runs with six, RBI with 20, and on-base percentage with .446. New York has a team batting average of .265 and a slugging percentage of .509. On Friday, New York will send Marcus Stroman to the mound. The right-hander is 0-0 with a 7.27 ERA, 6 Ks, and 4 BBs.

New York will pick up a victory at home on Friday when hosting San Francisco, but the play here is OVER. The OVER has cashed in 11 of San Francisco's last 12 on the road versus New York and in four of the last five overall between the Giants and the Yankees. San Francisco starter Robbie Ray has allowed four runs across 11.1 innings. New York starter Marcus Stroman has given up seven runs across 8.2 innings. Final Score Prediction, New York Yankees win but our best play is OVER 8-4.