Giants vs Twins Picks and Prediction – 5/10/2025

This Saturday, Logan Webb and the San Francisco Giants take on Joe Ryan and the Minnesota Twins at Target Field in a solid interleague matchup. Get our free MLB Picks all season long! The Giants, now 24-14, are coming off a strong 3-1 win over the Cubs on Wednesday and continue to ride a wave of excellent starting pitching.

Webb has been the tone-setter for San Francisco’s rotation, using pinpoint command and elite ground ball rates to work deep into games. He’ll look to challenge a Minnesota lineup that has shown more life in recent outings but still struggles with consistency, particularly against top-tier right-handed pitching.

The Twins, sitting at 18-20, are coming off a 5-2 win over the Orioles on Thursday. Joe Ryan has been one of the more reliable arms in Minnesota’s rotation and will be tasked with keeping San Francisco’s bats quiet while giving the Twins a shot to build an early lead.

Both pitchers thrive on limiting damage and working efficiently, so this could turn into a low-scoring, tightly contested game. Execution on defense and capitalizing with runners in scoring position may ultimately determine the outcome in what should be a sharp, clean ballgame.

With Webb pitching at a high level and the Giants playing consistent baseball, San Francisco holds the edge in this matchup. Ryan will keep things close, but San Francisco’s ability to execute in key moments gives them the advantage. Take the Giants to win this one. Final Score Prediction, San Francisco Giants win 4-2.