Giants vs Astros Picks and Prediction – 4/2/2025

The San Francisco Giants play the second game of a three-game series on the road Tuesday versus the Houston Astros. San Francisco is 2-1 following its 6-3 victory over the Cincinnati Reds on Sunday. Chapman hit a two-run homer, and Heliot Ramos hit a solo shot for the Giants in Sunday’s win. The Giants won two out of three over Cincinnati in the opening series of the season. Keep up to date with all the MLB action with our MLB previews.

Heliot Ramos is batting .333 with two home runs, four RBI, and four hits to lead San Francisco in each of the four categories. Jung Hoo Lee is the leader in on-base percentage at .417. San Francisco is batting .214 with a .408 slugging percentage. On Tuesday, San Francisco will send Logan Webb to the mound. The right-hander is 0-0 with a 5.40 ERA, 5 Ks, and 3 BBs.

The Houston Astros are 2-1 following a 2-1 victory over the New York Mets on Saturday. The Astros were off on Sunday. Jeremy Pena homered for Houston in the win, and Yordan Alvarez had his first hit of the season, which was an RBI-double that broke a tie in the sixth inning. Houston opened the season with a 3-1 victory over the Mets, followed by a loss on Friday to New York 3-1. 

Jose Altuve is batting .455 to lead Houston, and the left fielder has team highs in hits with five and an on-base percentage of .500. Jeremy Pena has Houston's only home run of the season, while Yordan Alvarez is the leader in RBI with two. On Tuesday, Houston will send Hayden Wesneski to the mound. Last season, the right-hander was 3-6 with a 3.86 ERA, 67 Ks, and 21 BBs. 

The Houston Astros have won two of the first three to open the season over the New York Mets and received excellent pitching, which was not expected against a tough New York lineup. Houston is currently first in Quality Starts with three, second in ERA at 1.33, first in batting average allowed at .136, and second in WHIP with 0.93. Final Score Prediction Houston Astros win 6-2.