Giants vs Astros Picks and Prediction – 4/1/2025

The San Francisco Giants open a three-game series on the road Monday versus the Houston Astros. San Francisco is 1-1 following its 3-2 loss to the Cincinnati Reds on Saturday. Justin Verlander’s debut for San Francisco did not go as planned for the three-time Cy Young Award winner. The Giants opened the season with a 6-4 victory over the Reds on Thursday. Keep up to date with all the MLB action with our MLB previews.

Wilmer Flores is batting .250 with two home runs, four RBI, and two hits to lead San Francisco in each of the four categories. Jung Hoo Lee is the leader in on-base percentage at .375. San Francisco is batting .215 with a .385 slugging percentage. San Francisco has not yet announced its starting pitcher for Monday's opening game of a three-game set with Houston.

The Houston Astros are 2-1 following a 2-1 victory over the New York Mets on Saturday. Jeremy Pena homered for Houston in the win, and Yordan Alvarez had his first hit of the season, which was an RBI double that broke a tie in the sixth inning. Houston opened the season with a 3-1 victory over the Mets, followed by a loss on Friday to New York 3-1. 

Jose Altuve is batting .455 to lead Houston, and the left fielder has team highs in hits with five and an on-base percentage of .500. Jeremy Pena has Houston's only home run of the season, while Yordan Alvarez is the leader in RBI with two. On Monday, the Houston Astros will send Ronel Blanco to the mound. Last season, the right-hander was 13-6 with a 2.80 ERA and 166 Ks. 

Although the Houston pitching staff was not expected to be the strength of the Astros this season, after three games of the regular season, the hurlers are performing well for the Astros. The Astros have a team ERA of just 1.33 and a 0.93 WHIP. San Francisco will be playing on Sunday prior to visiting Houston on Monday, while we Astros have a Sunday off, which is rare in baseball. Final Score Prediction, Houston Astros win 6-2.