Giants vs Tigers Picks and Prediction – 5/27/2025

In Tuesday night MLB interleague action, the San Francisco Giants and the Detroit Tigers will continue their series from Comerica Park. Be ready for the baseball season with all of our MLB predictions. The Giants (31-23) have split their first 28 road games and are 1.5 games behind Los Angeles for the top spot in the NL West Division. On Monday, San Francisco DH Wilmer Flores went 2-for-4 with an RBI during a 3-1 road loss. 

Twenty-eight year old righty Logan Webb (5-4 2.67 ERA) will head to the hill for the Giants in this contest. Last time out, Webb (4 IP) was roughed up for ten hits and six runs (3 ER) during an 8-4 home loss versus Kansas City.

The Detroit Tigers have won 19 of their first 27 home games and hold a 4.5 game lead for first place in the AL Central Division. During yesterday’s home victory, OF Riley Greene extended Detroit’s advantage with a two-run single in the fifth inning. SP Keider Montero (2-1) fired five shutout frames to earn the win for the Tigers, who improved to 35-20 overall.

Detroit skipper A.J. Hinch will give the nod to talented right-hander Jack Flaherty (2-6 4.39 ERA) on Tuesday. Through 53 plus innings, Flaherty has struck out 64 batters and owns a solid 1.18 WHIP.

San Francisco SP Justin Verlander has been placed on the 15-day injured list with right pectoral soreness. Through 54 games, San Francisco ranks 21st in OPS and 11th in runs scored. For the season, Detroit ranks 8th in OPS and 4th in runs scored. Take the Giants to win on the road. Final Score Prediction, San Francisco Giants win 4-3.