Giants vs Cubs Picks and Prediction – 5/7/2025

Historic Wrigley Field will play host to a Wednesday afternoon MLB clash between the San Francisco Giants and the Chicago Cubs. Be ready for the baseball season with all of our MLB predictions. The Giants (23-14) are two games above .500 on the road and are two games out of first place in the NL West Division. Last night, OF Jung Hoo Lee went 3-for-6 with a home run and three RBIs to lead San Francisco to a 14-5 road victory against Chicago in 11 innings. 

When healthy, San Francisco southpaw Robbie Ray (4-0 3.05 ERA) still has a quality arsenal of pitches. The Giants have been victorious in each of Ray’s first seven starts and he has retired 41 batters by strikes across 38 plus frames. 

The Chicago Cubs have won ten of their first 18 home games and hold a 3.5 game lead for the top spot in the NL Central Division. During Tuesday’s home loss, Chicago RP Ryan Pressly surrendered nine runs (8 ER) and did not record an out in the 11th inning. SS Dansby Swanson went 2-for-4 and scored twice for the Cubs, who fell to 22-15 overall.

Chicago skipper Craig Counsell will counter with right-hander Ben Brown (3-2 4.88 ERA) on Wednesday. Last time out, Brown fired six shutout frames and allowed just four hits during a 10-0 road triumph against Milwaukee. 

Chicago SP Shota Imanaga has been placed on the 15-day injured list with a mild left hamstring strain. Through 37 games, San Francisco ranks 17th in OPS and 12th in runs scored. For the season, Chicago ranks 3rd in OPS and 1st in runs scored. Take the Giants to win on the road. Final Score Prediction, San Francisco Giants win 4-3.