Giants vs Cubs Picks and Prediction – 5/5/2025

On Monday, the San Francisco Giants open a three-game series in the Windy City versus the Chicago Cubs. San Francisco is 21-13 following a 6-3 victory over the Colorado Rockies on Saturday. Matt Chapman hit a grand slam for San Francisco. The Giants are third in the National League West, 2 ½ games behind the first-place Los Angeles Dodgers. Keep up to date with all the MLB action with our MLB predictions.

Jung Hoo Lee is batting .312 with 39 hits to lead San Francisco in both. Wilmer Flores is the leader in home runs with seven and RBI with 29, while Mike Yastrzemski is the leader in on-base percentage at .378. San Francisco is batting .227 with a .380 slugging percentage. On Monday, the Giants will send Landen Roupp to the mound. The right-hander is 2-2 with a 5.10 ERA, 35 Ks, and 14 BBs.

The Chicago Cubs improved to 21-13 following Saturday’s 6-2 victory over the Milwaukee Brewers. Pete Crow-Armstrong homered for the third time in the last two games. Dansby Swanson also hit a home run for Chicago. The Cubs have won three straight and four of the last five. Chicago leads the National League Central by three games over the Cincinnati Reds.

Nico Hoerner is batting .288 to lead Chicago, and Ian Happ is the leader in hits with 41. Kyle Tucker leads Chicago in home runs with nine, RBI with 30, and on-base percentage at .390. Chicago is batting .265 with a .462 percentage. On Monday, the Chicago Cubs will send Matthew Boyd to the mound. The left-hander is 2-2 with a 2.70 ERA, 30 Ks, and 13 BBs.

The play here is OVER. The OVER has cashed in 10 of San Francisco's last 14 versus an opponent from the National League, and in six of Chicago's last seven played in May. San Francisco starter Landen Roupp has been hit hard in two straight outings, allowing seven runs on 13 hits across eight innings. Chicago starter Matthew Boyd has been hit hard in four straight outings, allowing 10 runs across 22.1 innings. Final Score Prediction: Chicago Cubs win but our best play is OVER 8-4.