Padres vs Blue Jays Picks and Prediction – 5/20/2025

The San Diego Padres open the three-game series on the road Tuesday versus the Toronto Blue Jays. San Diego dropped to 27-18 following Sunday’s 6-1 loss to the Seattle Mariners. San Diego was swept by Seattle in their three-game series. The Padres are second in the National League West, one game behind the first-place Los Angeles Dodgers. Keep up to date with all the MLB action with our expert MLB picks.

Manny Machado is batting .317 with 52 hits and an on-base percentage of .389 to lead San Diego in the three categories. Fernando Tatis Jr is the leader in home runs with 12 and RBI 27. San Diego is batting .261 with a .328 slugging percentage. On Tuesday, the Padres will send Dylan Cease to the mound. The right-hander is 1-2 with a 4.60 ERA, 58 Ks, and 18 BBs.

The Toronto Blue Jays dropped to 22-24 following Sunday’s 3-2 loss to the Detroit Tigers. Toronto lost two out of three in its series with Detroit over the weekend, and the Blue Jays have dropped four of the last six. Toronto has struggled to score runs as the Blue Jays are 23rd in baseball, averaging 3.89 runs per game. Toronto trails the first-place New York Yankees in the American League East by five games. 

Bo Bichette is batting .292 to lead Toronto and has team-highs in RBI with 22 and hits with 57. Daulton Varsho is the leader in home runs with six, and Vladimir Guerrero Jr is the leader in on-base percentage at .394. On Tuesday, the Toronto Blue Jays will send Chris Bassitt to the mound. The right-hander is 3-2 with a 3.16 ERA, 55 Ks, and 10 BBs.

San Diego will win on the road Tuesday when visiting Toronto, but the play here is OVER. The OVER has cashed in four of San Diego's last five on the road and 10 of Toronto's last 14 overall. San Diego starter Dylan Cease has had three consecutive strong outings, allowing five runs across 17.1 innings. Toronto starter Chris Bassitt has struggled in four of the last five starts, allowing 16 runs across 28 innings. Final Score Prediction: San Diego Padres win, but our best play is OVER 7-5