Padres vs Giants Picks and Prediction – 6/5/2025

This Wednesday, Nick Pivetta leads the San Diego Padres into a rematch against Kyle Harrison and the San Francisco Giants, fresh off a razor-thin 1-0, 10-inning win. Get our free MLB Picks all season long! The Padres will look to ride the momentum from their clutch performance while the Giants aim to bounce back and even the series.

Pivetta will be making his first start for the Padres, and expectations are high. Known for his strikeout potential and occasional inconsistency, Pivetta’s ability to command the strike zone will be key against a disciplined Giants lineup. His transition to the National League is one storyline to follow, especially in a low-margin matchup like this.

Harrison, on the other side, is coming off a tough-luck loss where he pitched deep into the game but received zero run support. He’ll be tasked with containing a Padres lineup that’s been getting clutch hits from the middle of the order. If Harrison keeps his pitch count down, he could again go deep into the game.

Expect another tight contest. Both lineups have been quiet, and these young arms have something to prove. In a game where one swing might decide it, defense and bullpen efficiency will likely make the difference again.

This matchup should remain close with both starters dealing and runs at a premium. Expect the Padres to edge it again with late-game execution and bullpen depth proving decisive. Take the Padres to bullpen to step up big and for San Diego to win this one. Final score prediction, San Diego Padres win 2-1.