Padres vs Athletics Picks and Prediction – 4/9/2025

The San Diego Padres conclude a three-game series on the road Wednesday versus the Athletics. San Diego is 9-2 and first in the National League West, a half-game ahead of San Francisco and Los Angeles. The Padres won the opening game of this series 5-4 on Monday. Jake Cronenworth hit a two-run homer for the Padres, and Fernando Tatis Jr belted a solo shot. Keep up to date with all the MLB action with ourMLB previews.

Fernando Tatis Jr is batting .381 with 16 and an on-base percentage of .449 to lead San Diego in each of the three categories. Jackson Merrill is leading San Diego in home runs with three and RBI with 10. San Diego has a team batting average of .282 and a slugging percentage of .422. On Wednesday, San Diego will send Randy Vasquez to the mound. The right-hander is 0-1 with a 1.69 ERA, 5 Ks, and 9 BBs.

The Athletics dropped to 4-7 following Monday’s one-run loss to the Padres. The Athletics are last in the American League West, four games behind first-place Texas. The Athletics have lost two straight and six of the last eight. The club is struggling on the mound with an ERA of 5.60, which is 29th, and opponents are hitting .272, which is 26th. 

Tyler Soderstrom is batting .381 with six home runs, 10 RBI, 16 hits, and an on-base percentage of 4.35 to lead the Athletics in each of the five categories. The Athletics have a team batting average of .242 and a slugging percentage of .416. On Wednesday, the Athletics will send Osvaldo Bido to the mound. The right-hander is 1-0 with a 2.70 ERA, 9 Ks, and 6 BBs.

The San Diego Padres will continue their strong start with a victory on the road Wednesday when completing a three-game series with the Athletics, but the play here is OVER. The OVER has cashed in six of San Diego's last eight played on the road, and six of the Athletics’ last seven overall, and eight of the Athletics' last 11 head to head versus the Padres, including Monday night’s first game of the series. Final Score Prediction, San Diego Padres win but our best play is OVER 7-3.